Drug interactions
Sirolimus + Tolvaptan
Severity: Minor
Sirolimus and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are P-gp substrates and may inhibit P-gp, so each could modestly raise the other's exposure. Clinical significance is uncertain.
What this interaction means in plain words
Sirolimus and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sirolimus belongs to Miscellaneous; Tolvaptan belongs to Endocrine.
Why it happens
Possible mutual competition for or inhibition of P-glycoprotein efflux.
What to do
Monitor sirolimus trough levels and tolvaptan effects such as serum sodium and thirst or volume status after starting the combination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Sirolimus with Tolvaptan?
MediHelp rates the interaction as minor. Sirolimus and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are P-gp substrates and may inhibit P-gp, so each could modestly raise the other's exposure. Clinical significance is uncertain.
How serious is the interaction between Sirolimus and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels and tolvaptan effects such as serum sodium and thirst or volume status after starting the combination.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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