Drug interactions
Sirolimus + Trandolapril
Severity: Major
Sirolimus and Trandolapril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus increases the risk of angioedema in patients taking ACE inhibitors. Swelling of the face, tongue or airway can be serious.
What this interaction means in plain words
Sirolimus and Trandolapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sirolimus belongs to Miscellaneous; Trandolapril belongs to Cardiovascular.
Why it happens
Both impair bradykinin degradation pathways, leading to bradykinin accumulation.
What to do
Counsel patients to seek urgent care for facial, tongue or throat swelling. Consider a non-ACE inhibitor antihypertensive if angioedema occurs or risk is high.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Sirolimus with Trandolapril?
MediHelp rates the interaction as major. Sirolimus and Trandolapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sirolimus increases the risk of angioedema in patients taking ACE inhibitors. Swelling of the face, tongue or airway can be serious.
How serious is the interaction between Sirolimus and Trandolapril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to seek urgent care for facial, tongue or throat swelling. Consider a non-ACE inhibitor antihypertensive if angioedema occurs or risk is high.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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