Drug interactions
Sirolimus + Trastuzumab
Severity: Moderate
Sirolimus and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab can add to myelosuppression and infection risk when given with immunosuppressants such as sirolimus. Neutropenia is more frequent when trastuzumab is used with chemotherapy.
What this interaction means in plain words
Sirolimus and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sirolimus belongs to Miscellaneous; Trastuzumab belongs to Oncology.
Why it happens
Additive immunosuppressive and hematologic effects; no pharmacokinetic interaction is established.
What to do
Monitor blood counts and signs of infection during combined therapy, and reassess immunosuppression if neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Trastuzumab
Frequently asked questions
Can I take Sirolimus with Trastuzumab?
MediHelp rates the interaction as moderate. Sirolimus and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab can add to myelosuppression and infection risk when given with immunosuppressants such as sirolimus. Neutropenia is more frequent when trastuzumab is used with chemotherapy.
How serious is the interaction between Sirolimus and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of infection during combined therapy, and reassess immunosuppression if neutropenia occurs.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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