Drug interactions
Sirolimus + Ublituximab
Severity: Moderate
Sirolimus and Ublituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ublituximab depletes B cells and sirolimus suppresses lymphocyte function, so together they increase the risk of serious infections.
What this interaction means in plain words
Sirolimus and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sirolimus belongs to Miscellaneous; Ublituximab belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic immunosuppression.
What to do
Monitor for signs of infection and consider the duration of B-cell depletion when planning other immunosuppressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Ublituximab
Frequently asked questions
Can I take Sirolimus with Ublituximab?
MediHelp rates the interaction as moderate. Sirolimus and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ublituximab depletes B cells and sirolimus suppresses lymphocyte function, so together they increase the risk of serious infections.
How serious is the interaction between Sirolimus and Ublituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and consider the duration of B-cell depletion when planning other immunosuppressants.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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