Drug interactions
Sirolimus + Vincristine
Severity: Minor
Sirolimus and Vincristine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus is a P-glycoprotein substrate and weak inhibitor and may modestly increase vincristine exposure. Clinically important changes are uncommon, but vincristine neurotoxicity may be enhanced.
What this interaction means in plain words
Sirolimus and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sirolimus belongs to Miscellaneous; Vincristine belongs to Oncology.
Why it happens
Sirolimus may competitively inhibit P-glycoprotein efflux of vincristine.
What to do
Monitor for neuropathy and constipation; adjust the vincristine dose only if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Sirolimus with Vincristine?
MediHelp rates the interaction as minor. Sirolimus and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sirolimus is a P-glycoprotein substrate and weak inhibitor and may modestly increase vincristine exposure. Clinically important changes are uncommon, but vincristine neurotoxicity may be enhanced.
How serious is the interaction between Sirolimus and Vincristine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy and constipation; adjust the vincristine dose only if toxicity occurs.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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