Drug interactions
Sitagliptin + Tolazamide
Severity: Moderate
Sitagliptin and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sitagliptin combined with a sulfonylurea increases the risk of hypoglycemia, as labeling for DPP-4 inhibitors notes. A lower sulfonylurea dose is often used.
What this interaction means in plain words
Sitagliptin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sitagliptin belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Additive insulin secretion from sulfonylurea and DPP-4 inhibition prolonging incretin activity.
What to do
Consider reducing the tolazamide dose when adding sitagliptin and monitor blood glucose. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Sitagliptin with Tolazamide?
MediHelp rates the interaction as moderate. Sitagliptin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sitagliptin combined with a sulfonylurea increases the risk of hypoglycemia, as labeling for DPP-4 inhibitors notes. A lower sulfonylurea dose is often used.
How serious is the interaction between Sitagliptin and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the tolazamide dose when adding sitagliptin and monitor blood glucose. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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