Drug interactions
Smallpox vaccine live + Temsirolimus
Severity: Contraindicated
Smallpox vaccine live and Temsirolimus: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live vaccinia vaccine can cause progressive vaccinia and serious disseminated infection in immunosuppressed patients such as those on temsirolimus. Vaccine efficacy may also be reduced.
What this interaction means in plain words
Smallpox vaccine live and Temsirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
mTOR-mediated immunosuppression impairs control of replicating vaccinia virus.
What to do
Avoid live smallpox vaccine during temsirolimus therapy. Seek infectious disease or public health advice on non-replicating alternatives if exposure risk exists.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Smallpox vaccine live with Temsirolimus?
MediHelp rates the interaction as contraindicated. Smallpox vaccine live and Temsirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live vaccinia vaccine can cause progressive vaccinia and serious disseminated infection in immunosuppressed patients such as those on temsirolimus. Vaccine efficacy may also be reduced.
How serious is the interaction between Smallpox vaccine live and Temsirolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live smallpox vaccine during temsirolimus therapy. Seek infectious disease or public health advice on non-replicating alternatives if exposure risk exists.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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