Drug interactions
Sofosbuvir + Tenofovir disoproxil
Severity: Moderate
Sofosbuvir and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sofosbuvir-containing regimens, especially those with velpatasvir or ledipasvir, can raise tenofovir exposure, likely through P-gp inhibition by the partner drug. Higher tenofovir levels raise the risk of renal adverse effects, especially when boosted antiretrovirals are also used.
What this interaction means in plain words
Sofosbuvir and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of intestinal P-glycoprotein by combination partners (ledipasvir or velpatasvir) increases tenofovir absorption; sofosbuvir alone has little effect.
What to do
Monitor renal function, including creatinine clearance and phosphate, during co-treatment. Consider tenofovir alafenamide if renal risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir
Frequently asked questions
Can I take Sofosbuvir with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Sofosbuvir and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sofosbuvir-containing regimens, especially those with velpatasvir or ledipasvir, can raise tenofovir exposure, likely through P-gp inhibition by the partner drug. Higher tenofovir levels raise the risk of renal adverse effects, especially when boosted antiretrovirals are also used.
How serious is the interaction between Sofosbuvir and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, including creatinine clearance and phosphate, during co-treatment. Consider tenofovir alafenamide if renal risk is high.
What other medicines interact with Sofosbuvir?
MediHelp also lists interactions of Sofosbuvir with, for example, Amiodarone, Apalutamide, Carbamazepine. The full list is on the Sofosbuvir page.
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