Drug interactions
Sofosbuvir / velpatasvir + Temsirolimus
Severity: Minor
Sofosbuvir / velpatasvir and Temsirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits P-glycoprotein and could modestly raise temsirolimus exposure. The effect is likely small since temsirolimus is mainly cleared by CYP3A4.
What this interaction means in plain words
Sofosbuvir / velpatasvir and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Velpatasvir inhibits intestinal and other P-gp, potentially reducing temsirolimus efflux.
What to do
No routine dose change; monitor for temsirolimus toxicity such as mucositis, cytopenias and hyperglycemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Sofosbuvir / velpatasvir with Temsirolimus?
MediHelp rates the interaction as minor. Sofosbuvir / velpatasvir and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir inhibits P-glycoprotein and could modestly raise temsirolimus exposure. The effect is likely small since temsirolimus is mainly cleared by CYP3A4.
How serious is the interaction between Sofosbuvir / velpatasvir and Temsirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for temsirolimus toxicity such as mucositis, cytopenias and hyperglycemia.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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