Drug interactions
Sofosbuvir-velpatasvir + Tipranavir
Severity: Major
Sofosbuvir-velpatasvir and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, has mixed effects on P-gp and CYP3A4, and has been described as a P-gp inducer. Induction may lower sofosbuvir and velpatasvir exposure and risk loss of antiviral efficacy and virologic failure. Labeling advises against combining these agents.
What this interaction means in plain words
Sofosbuvir-velpatasvir and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sofosbuvir-velpatasvir belongs to Anti Virals; Tipranavir belongs to Anti Virals.
Why it happens
Tipranavir/ritonavir induces P-gp and CYP enzymes, which can lower sofosbuvir and velpatasvir concentrations.
What to do
Avoid coadministration and choose an alternative antiretroviral to tipranavir or a different HCV regimen. If it cannot be avoided, monitor HCV RNA closely for treatment failure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Sofosbuvir-velpatasvir with Tipranavir?
MediHelp rates the interaction as major. Sofosbuvir-velpatasvir and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir, given with ritonavir, has mixed effects on P-gp and CYP3A4, and has been described as a P-gp inducer. Induction may lower sofosbuvir and velpatasvir exposure and risk loss of antiviral efficacy and virologic failure. Labeling advises against combining these agents.
How serious is the interaction between Sofosbuvir-velpatasvir and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and choose an alternative antiretroviral to tipranavir or a different HCV regimen. If it cannot be avoided, monitor HCV RNA closely for treatment failure.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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