Drug interactions
Sofosbuvir-velpatasvir + Voriconazole
Severity: Minor
Sofosbuvir-velpatasvir and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and may modestly increase velpatasvir exposure. Velpatasvir has several metabolic pathways, so the effect is expected to be small and is generally not clinically significant.
What this interaction means in plain words
Sofosbuvir-velpatasvir and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sofosbuvir-velpatasvir belongs to Anti Virals; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, one of several enzymes metabolizing velpatasvir.
What to do
No dose adjustment is required; monitor for velpatasvir adverse effects such as headache and fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Sofosbuvir-velpatasvir with Voriconazole?
MediHelp rates the interaction as minor. Sofosbuvir-velpatasvir and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole inhibits CYP3A4 and may modestly increase velpatasvir exposure. Velpatasvir has several metabolic pathways, so the effect is expected to be small and is generally not clinically significant.
How serious is the interaction between Sofosbuvir-velpatasvir and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor for velpatasvir adverse effects such as headache and fatigue.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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