Drug interactions
Sofosbuvir-velpatasvir-voxilaprevir + Sotorasib
Severity: Moderate
Sofosbuvir-velpatasvir-voxilaprevir and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-glycoprotein substrate that also induces CYP3A4 and may affect P-gp, so its effect on the HCV combination is uncertain and not well characterised. Any reduction in sofosbuvir or voxilaprevir exposure could compromise cure rates, while changes in sotorasib exposure are also possible.
What this interaction means in plain words
Sofosbuvir-velpatasvir-voxilaprevir and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals; Sotorasib belongs to Oncology.
Why it happens
Sotorasib may modulate P-glycoprotein and CYP3A4, altering absorption of P-gp substrates; the direction and size of the effect are not firmly established.
What to do
If coadministration is needed, monitor HCV viral response and sotorasib tolerability. Consider alternative acid-reducing or HCV regimens if virologic response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Sofosbuvir-velpatasvir-voxilaprevir with Sotorasib?
MediHelp rates the interaction as moderate. Sofosbuvir-velpatasvir-voxilaprevir and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a P-glycoprotein substrate that also induces CYP3A4 and may affect P-gp, so its effect on the HCV combination is uncertain and not well characterised. Any reduction in sofosbuvir or voxilaprevir exposure could compromise cure rates, while changes in sotorasib exposure are also possible.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministration is needed, monitor HCV viral response and sotorasib tolerability. Consider alternative acid-reducing or HCV regimens if virologic response is inadequate.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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