Drug interactions
Solifenacin + Sorafenib
Severity: Moderate
Solifenacin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib is associated with QT prolongation, and solifenacin can add to this effect, raising the possibility of arrhythmia. The risk is greater with electrolyte disturbances or other QT-prolonging drugs.
What this interaction means in plain words
Solifenacin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Solifenacin belongs to Genitourinary; Sorafenib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Perform a baseline ECG and monitor the QTc and electrolytes during treatment. Consider an alternative to solifenacin if QT prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Sorafenib
Frequently asked questions
Can I take Solifenacin with Sorafenib?
MediHelp rates the interaction as moderate. Solifenacin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib is associated with QT prolongation, and solifenacin can add to this effect, raising the possibility of arrhythmia. The risk is greater with electrolyte disturbances or other QT-prolonging drugs.
How serious is the interaction between Solifenacin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform a baseline ECG and monitor the QTc and electrolytes during treatment. Consider an alternative to solifenacin if QT prolongation develops.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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