Drug interactions
Solifenacin + Sunitinib
Severity: Moderate
Solifenacin and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib can prolong the QT interval, and solifenacin can contribute further, raising the risk of torsades de pointes. Sunitinib is also a CYP3A4 substrate, but the main concern is cardiac repolarization.
What this interaction means in plain words
Solifenacin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Solifenacin belongs to Genitourinary; Sunitinib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Check the ECG and electrolytes at baseline and periodically during therapy. Correct hypokalemia and hypomagnesemia and avoid further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Solifenacin with Sunitinib?
MediHelp rates the interaction as moderate. Solifenacin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sunitinib can prolong the QT interval, and solifenacin can contribute further, raising the risk of torsades de pointes. Sunitinib is also a CYP3A4 substrate, but the main concern is cardiac repolarization.
How serious is the interaction between Solifenacin and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the ECG and electrolytes at baseline and periodically during therapy. Correct hypokalemia and hypomagnesemia and avoid further QT-prolonging drugs.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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