Drug interactions
Solifenacin + Tolterodine
Severity: Moderate
Solifenacin and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinic agents for overactive bladder, so combining them duplicates therapy and adds dry mouth, constipation, blurred vision, urinary retention and cognitive effects. Both may also prolong QT slightly.
What this interaction means in plain words
Solifenacin and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Solifenacin belongs to Genitourinary; Tolterodine belongs to Genitourinary.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid concurrent use of two antimuscarinics and optimize a single agent. Monitor for anticholinergic toxicity if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Solifenacin
Frequently asked questions
Can I take Solifenacin with Tolterodine?
MediHelp rates the interaction as moderate. Solifenacin and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinic agents for overactive bladder, so combining them duplicates therapy and adds dry mouth, constipation, blurred vision, urinary retention and cognitive effects. Both may also prolong QT slightly.
How serious is the interaction between Solifenacin and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two antimuscarinics and optimize a single agent. Monitor for anticholinergic toxicity if combined.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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