Drug interactions
Solifenacin + Triptorelin
Severity: Moderate
Solifenacin and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptorelin, as androgen deprivation therapy, may prolong the QT interval, and solifenacin may add to this effect. The risk is mostly relevant in men with other cardiac risk factors.
What this interaction means in plain words
Solifenacin and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Solifenacin belongs to Genitourinary; Triptorelin belongs to Endocrine.
Why it happens
Additive effects on cardiac repolarization.
What to do
Check the ECG and electrolytes in patients with cardiac risk factors and monitor the QTc during treatment. Reassess the need for solifenacin if the QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Triptorelin
Frequently asked questions
Can I take Solifenacin with Triptorelin?
MediHelp rates the interaction as moderate. Solifenacin and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptorelin, as androgen deprivation therapy, may prolong the QT interval, and solifenacin may add to this effect. The risk is mostly relevant in men with other cardiac risk factors.
How serious is the interaction between Solifenacin and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the ECG and electrolytes in patients with cardiac risk factors and monitor the QTc during treatment. Reassess the need for solifenacin if the QTc is prolonged.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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