Drug interactions
Solifenacin + Trospium
Severity: Moderate
Solifenacin and Trospium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are bladder antimuscarinics, so combining them mainly adds adverse effects without clear extra benefit. Dry mouth, constipation, blurred vision and urinary retention become more likely.
What this interaction means in plain words
Solifenacin and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Solifenacin belongs to Genitourinary; Trospium belongs to Genitourinary.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid using two antimuscarinics for overactive bladder together; optimize a single agent or switch class. If combined, monitor post-void residual and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trospium
- Clozapine + Trospium Major
- Pramlintide + Trospium Major
- Thioridazine + Trospium Major
- Trihexyphenidyl + Trospium Major
- Aclidinium + Trospium Moderate
- Amantadine + Trospium Moderate
Other interactions of Solifenacin
Frequently asked questions
Can I take Solifenacin with Trospium?
MediHelp rates the interaction as moderate. Solifenacin and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are bladder antimuscarinics, so combining them mainly adds adverse effects without clear extra benefit. Dry mouth, constipation, blurred vision and urinary retention become more likely.
How serious is the interaction between Solifenacin and Trospium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two antimuscarinics for overactive bladder together; optimize a single agent or switch class. If combined, monitor post-void residual and anticholinergic effects.
What other medicines interact with Trospium?
MediHelp also lists interactions of Trospium with, for example, Clozapine, Pramlintide, Thioridazine. The full list is on the Trospium page.
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