Drug interactions
Sorafenib + Tacrolimus
Severity: Moderate
Sorafenib and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus and sorafenib can each prolong the QT interval, so combined use may raise arrhythmia risk. Tacrolimus also causes hypomagnesemia and hyperkalemia, which may add to rhythm instability.
What this interaction means in plain words
Sorafenib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sorafenib belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG, potassium and magnesium, and correct abnormalities. Watch tacrolimus trough levels and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Sorafenib with Tacrolimus?
MediHelp rates the interaction as moderate. Sorafenib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus and sorafenib can each prolong the QT interval, so combined use may raise arrhythmia risk. Tacrolimus also causes hypomagnesemia and hyperkalemia, which may add to rhythm instability.
How serious is the interaction between Sorafenib and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and magnesium, and correct abnormalities. Watch tacrolimus trough levels and renal function.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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