Drug interactions
Sorafenib + Tipranavir
Severity: Moderate
Sorafenib and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, is a strong CYP3A4 inhibitor, although sorafenib is cleared mainly by CYP3A4 oxidation and UGT1A9 glucuronidation. Sorafenib exposure may rise modestly, which could increase adverse effects such as hand-foot skin reaction, hypertension and diarrhea.
What this interaction means in plain words
Sorafenib and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sorafenib belongs to Oncology; Tipranavir belongs to Anti Virals.
Why it happens
Tipranavir/ritonavir inhibits CYP3A4-mediated metabolism of sorafenib, although it also has some inducing effects on other pathways.
What to do
Monitor for sorafenib toxicity such as skin reactions, hypertension and diarrhea, and reduce the sorafenib dose or interrupt treatment if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Sorafenib with Tipranavir?
MediHelp rates the interaction as moderate. Sorafenib and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, given with ritonavir, is a strong CYP3A4 inhibitor, although sorafenib is cleared mainly by CYP3A4 oxidation and UGT1A9 glucuronidation. Sorafenib exposure may rise modestly, which could increase adverse effects such as hand-foot skin reaction, hypertension and diarrhea.
How serious is the interaction between Sorafenib and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sorafenib toxicity such as skin reactions, hypertension and diarrhea, and reduce the sorafenib dose or interrupt treatment if toxicity appears.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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