Drug interactions
Sorafenib + Trastuzumab deruxtecan
Severity: Moderate
Sorafenib and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause myelosuppression, and trastuzumab deruxtecan is associated with neutropenia and interstitial lung disease. Combined use may increase the risk of neutropenia and infection, although no formal interaction data exist.
What this interaction means in plain words
Sorafenib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sorafenib belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive pharmacodynamic bone marrow suppression; no pharmacokinetic interaction is established.
What to do
Monitor complete blood counts regularly and watch for fever or signs of infection. Delay or reduce doses according to each product's labeling for neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sorafenib and Trastuzumab deruxtecan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sorafenib
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Sorafenib with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Sorafenib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause myelosuppression, and trastuzumab deruxtecan is associated with neutropenia and interstitial lung disease. Combined use may increase the risk of neutropenia and infection, although no formal interaction data exist.
How serious is the interaction between Sorafenib and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and watch for fever or signs of infection. Delay or reduce doses according to each product's labeling for neutropenia.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
