Drug interactions
Sorafenib + Voriconazole
Severity: Moderate
Sorafenib and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib is partly metabolized by CYP3A4, and voriconazole is a strong inhibitor of this enzyme. Exposure to sorafenib may increase, raising the risk of hand-foot reaction, hypertension, diarrhea and hepatotoxicity. The clinical effect is generally modest because CYP3A4 is not the sole route of clearance.
What this interaction means in plain words
Sorafenib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sorafenib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4-mediated oxidative metabolism of sorafenib.
What to do
Monitor for sorafenib toxicity such as skin reactions, blood pressure rise and liver enzyme changes. Reduce the sorafenib dose if adverse effects become intolerable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Sorafenib with Voriconazole?
MediHelp rates the interaction as moderate. Sorafenib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib is partly metabolized by CYP3A4, and voriconazole is a strong inhibitor of this enzyme. Exposure to sorafenib may increase, raising the risk of hand-foot reaction, hypertension, diarrhea and hepatotoxicity. The clinical effect is generally modest because CYP3A4 is not the sole route of clearance.
How serious is the interaction between Sorafenib and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sorafenib toxicity such as skin reactions, blood pressure rise and liver enzyme changes. Reduce the sorafenib dose if adverse effects become intolerable.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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