Drug interactions
Sorafenib + Vorinostat
Severity: Moderate
Sorafenib and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been linked to QT prolongation. Their combined use may add to the risk of ventricular arrhythmias, particularly in patients with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Sorafenib and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sorafenib belongs to Oncology; Vorinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check a baseline ECG and electrolytes and correct any abnormalities. Repeat the ECG and electrolytes periodically during combined therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Sorafenib with Vorinostat?
MediHelp rates the interaction as moderate. Sorafenib and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been linked to QT prolongation. Their combined use may add to the risk of ventricular arrhythmias, particularly in patients with electrolyte disturbances or cardiac disease.
How serious is the interaction between Sorafenib and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and correct any abnormalities. Repeat the ECG and electrolytes periodically during combined therapy.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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