Drug interactions
Sotalol + Sulfamethoxazole
Severity: Moderate
Sotalol and Sulfamethoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole, usually given with trimethoprim, has been associated with rare QT prolongation and torsades, mostly in patients with other risk factors. With sotalol the risk may be additive, and trimethoprim may also contribute to hyperkalemia.
What this interaction means in plain words
Sotalol and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive QT prolongation; the mechanism for the antibiotic is not well established.
What to do
Where an alternative antibiotic is practical, prefer it. If used, check ECG, potassium, magnesium and renal function, especially in elderly or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Sotalol with Sulfamethoxazole?
MediHelp rates the interaction as moderate. Sotalol and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfamethoxazole, usually given with trimethoprim, has been associated with rare QT prolongation and torsades, mostly in patients with other risk factors. With sotalol the risk may be additive, and trimethoprim may also contribute to hyperkalemia.
How serious is the interaction between Sotalol and Sulfamethoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where an alternative antibiotic is practical, prefer it. If used, check ECG, potassium, magnesium and renal function, especially in elderly or renally impaired patients.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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