Drug interactions
Sotalol + Trifluoperazine
Severity: Major
Sotalol and Trifluoperazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine, a phenothiazine, can prolong the QT interval, and together with sotalol it increases the risk of torsades de pointes. Risk is higher with bradycardia, hypokalemia, or structural heart disease.
What this interaction means in plain words
Sotalol and Trifluoperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation through IKr channel blockade.
What to do
Avoid if possible and choose an antipsychotic with lower QT risk. If combined, obtain baseline ECG, correct electrolytes, and monitor QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Sotalol with Trifluoperazine?
MediHelp rates the interaction as major. Sotalol and Trifluoperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trifluoperazine, a phenothiazine, can prolong the QT interval, and together with sotalol it increases the risk of torsades de pointes. Risk is higher with bradycardia, hypokalemia, or structural heart disease.
How serious is the interaction between Sotalol and Trifluoperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose an antipsychotic with lower QT risk. If combined, obtain baseline ECG, correct electrolytes, and monitor QTc.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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