Drug interactions
Sotalol + Umeclidinium bromide / vilanterol inhaled
Severity: Major
Sotalol and Umeclidinium bromide / vilanterol inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is a non-selective beta-blocker and can antagonize the bronchodilating effect of vilanterol, risking bronchospasm in patients with airway disease. Vilanterol may also add to QT effects of sotalol and cause tachycardia or hypokalemia.
What this interaction means in plain words
Sotalol and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 receptors, plus additive cardiac repolarization effects.
What to do
Avoid sotalol in patients with COPD or asthma needing beta-agonists; if a beta-blocker is required, choose a cardioselective one. Monitor lung function, heart rate, potassium and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Sotalol with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as major. Sotalol and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol is a non-selective beta-blocker and can antagonize the bronchodilating effect of vilanterol, risking bronchospasm in patients with airway disease. Vilanterol may also add to QT effects of sotalol and cause tachycardia or hypokalemia.
How serious is the interaction between Sotalol and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid sotalol in patients with COPD or asthma needing beta-agonists; if a beta-blocker is required, choose a cardioselective one. Monitor lung function, heart rate, potassium and ECG.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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