Drug interactions
Sotalol + Vilanterol / fluticasone furoate inhaled
Severity: Major
Sotalol and Vilanterol / fluticasone furoate inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is a non-selective beta-blocker and can block the bronchodilating effect of inhaled vilanterol, risking bronchospasm in patients with asthma or COPD. Both agents can also affect QT interval and heart rhythm, so cardiac effects may be additive.
What this interaction means in plain words
Sotalol and Vilanterol / fluticasone furoate inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 receptors, plus additive QT and proarrhythmic effects.
What to do
Avoid in patients with reactive airway disease and consider an alternative antiarrhythmic. If sotalol is required, monitor respiratory status and ECG closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sotalol and Vilanterol / fluticasone furoate inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Sotalol with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as major. Sotalol and Vilanterol / fluticasone furoate inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol is a non-selective beta-blocker and can block the bronchodilating effect of inhaled vilanterol, risking bronchospasm in patients with asthma or COPD. Both agents can also affect QT interval and heart rhythm, so cardiac effects may be additive.
How serious is the interaction between Sotalol and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with reactive airway disease and consider an alternative antiarrhythmic. If sotalol is required, monitor respiratory status and ECG closely.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
