Drug interactions
Sotalol + Yohimbe
Severity: Moderate
Sotalol and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that raises blood pressure and heart rate, which can oppose the antihypertensive and rate-slowing effects of sotalol. Yohimbe may also provoke tachyarrhythmias.
What this interaction means in plain words
Sotalol and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between alpha-2 blockade-induced sympathetic activation and beta-blockade.
What to do
Avoid yohimbe in patients on sotalol; monitor blood pressure and heart rhythm if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Sotalol with Yohimbe?
MediHelp rates the interaction as moderate. Sotalol and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that raises blood pressure and heart rate, which can oppose the antihypertensive and rate-slowing effects of sotalol. Yohimbe may also provoke tachyarrhythmias.
How serious is the interaction between Sotalol and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yohimbe in patients on sotalol; monitor blood pressure and heart rhythm if used.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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