Drug interactions
Sparsentan + Sulindac
Severity: Major
Sparsentan and Sulindac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan blocks endothelin and angiotensin receptors, which lowers glomerular pressure, and NSAIDs further reduce renal perfusion. This may worsen kidney function and raise potassium.
What this interaction means in plain words
Sparsentan and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sparsentan belongs to Genitourinary; Sulindac belongs to Musculoskeletal.
Why it happens
Combined loss of afferent prostaglandin-mediated dilation (NSAID) and efferent dilation (angiotensin blockade) reduces glomerular filtration.
What to do
Avoid regular NSAID use; if unavoidable, monitor serum creatinine and potassium and stop the NSAID if renal function declines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Sparsentan with Sulindac?
MediHelp rates the interaction as major. Sparsentan and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sparsentan blocks endothelin and angiotensin receptors, which lowers glomerular pressure, and NSAIDs further reduce renal perfusion. This may worsen kidney function and raise potassium.
How serious is the interaction between Sparsentan and Sulindac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use; if unavoidable, monitor serum creatinine and potassium and stop the NSAID if renal function declines.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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