Drug interactions
Sparsentan + Topotecan
Severity: Moderate
Sparsentan and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan inhibits BCRP, a transporter involved in topotecan absorption and elimination. Exposure to topotecan may increase and worsen myelosuppression.
What this interaction means in plain words
Sparsentan and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sparsentan belongs to Genitourinary; Topotecan belongs to Oncology.
Why it happens
Inhibition of BCRP efflux transporter by sparsentan increases topotecan bioavailability and reduces clearance.
What to do
Avoid oral topotecan with sparsentan; with IV topotecan, monitor blood counts and consider dose reduction for toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Sparsentan with Topotecan?
MediHelp rates the interaction as moderate. Sparsentan and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan inhibits BCRP, a transporter involved in topotecan absorption and elimination. Exposure to topotecan may increase and worsen myelosuppression.
How serious is the interaction between Sparsentan and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral topotecan with sparsentan; with IV topotecan, monitor blood counts and consider dose reduction for toxicity.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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