Drug interactions
Sparsentan + Verapamil
Severity: Moderate
Sparsentan and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil, a moderate CYP3A4 inhibitor, can raise sparsentan exposure. This may increase hypotension, edema, hyperkalemia and effects on kidney function.
What this interaction means in plain words
Sparsentan and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sparsentan belongs to Genitourinary; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated metabolism of sparsentan by verapamil.
What to do
No empirical dose change is required, but monitor blood pressure, serum potassium, edema and renal function regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Sparsentan with Verapamil?
MediHelp rates the interaction as moderate. Sparsentan and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil, a moderate CYP3A4 inhibitor, can raise sparsentan exposure. This may increase hypotension, edema, hyperkalemia and effects on kidney function.
How serious is the interaction between Sparsentan and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is required, but monitor blood pressure, serum potassium, edema and renal function regularly.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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