Drug interactions
spironolactone + trimethoprim
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Severe hyperkalemia risk (esp. elderly/renal).
Mechanism of action
Additive K+ retention; TMP acts like K-sparing diuretic.
Clinical management
Avoid when possible; monitor K+/renal if used.
Drug reference
References
Frequently asked questions
Can I take spironolactone with trimethoprim?
The interaction is rated: Major. Severe hyperkalemia risk (esp. elderly/renal).
How serious is the interaction between spironolactone and trimethoprim?
The interaction is rated: Major. Evidence level: High.
How is the interaction between spironolactone and trimethoprim managed?
Avoid when possible; monitor K+/renal if used.
Why do spironolactone and trimethoprim interact?
Additive K+ retention; TMP acts like K-sparing diuretic.
Full monographs, dosing and an interaction checker in the MediHelp app
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