Drug interactions
Stiripentol + Tenofovir disoproxil
Severity: Minor
Stiripentol and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits P-gp and BCRP in vitro, which could increase tenofovir absorption and exposure. The clinical effect is not well characterized.
What this interaction means in plain words
Stiripentol and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal P-glycoprotein and BCRP efflux transporters.
What to do
Monitor renal function and tenofovir adverse effects; consider tenofovir alternatives if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Stiripentol and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits P-gp and BCRP in vitro, which could increase tenofovir absorption and exposure. The clinical effect is not well characterized.
How serious is the interaction between Stiripentol and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and tenofovir adverse effects; consider tenofovir alternatives if toxicity occurs.
What other medicines interact with Stiripentol?
MediHelp also lists interactions of Stiripentol with, for example, Apalutamide, Clomipramine, Ergotamine. The full list is on the Stiripentol page.
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