Drug interactions
Stiripentol + Theophylline
Severity: Moderate
Stiripentol and Theophylline: moderate interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces CYP1A2 and CYP3A4, so theophylline exposure may change in either direction. Given theophylline's narrow therapeutic index, toxicity or loss of effect may occur.
What this interaction means in plain words
Stiripentol and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Theophylline belongs to Respiratory.
Why it happens
Mixed inhibition and induction of CYP1A2 and CYP3A4 by stiripentol alters theophylline metabolism.
What to do
Measure theophylline levels when stiripentol is started, stopped or its dose changed, and adjust the theophylline dose to the level and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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References
- Diacomit - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Theophylline?
MediHelp rates the interaction as moderate. Stiripentol and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces CYP1A2 and CYP3A4, so theophylline exposure may change in either direction. Given theophylline's narrow therapeutic index, toxicity or loss of effect may occur.
How serious is the interaction between Stiripentol and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure theophylline levels when stiripentol is started, stopped or its dose changed, and adjust the theophylline dose to the level and clinical response.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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