Drug interactions
Stiripentol + Thiotepa
Severity: Moderate
Stiripentol and Thiotepa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP3A4 and CYP2B6 and may alter the conversion of thiotepa to its active metabolite and its clearance. The clinical effect on toxicity or efficacy is uncertain.
What this interaction means in plain words
Stiripentol and Thiotepa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Thiotepa belongs to Oncology.
Why it happens
Inhibition of CYP3A4 and CYP2B6 metabolism of thiotepa by stiripentol.
What to do
Avoid the combination where possible. If used together, monitor for myelosuppression and adjust the thiotepa dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Stiripentol
Other interactions of Thiotepa
- Bendamustine + Thiotepa Major
- Chlorambucil + Thiotepa Major
- Clarithromycin + Thiotepa Major
- Cyclophosphamide + Thiotepa Major
- Dacarbazine + Thiotepa Major
- Deferiprone + Thiotepa Major
Frequently asked questions
Can I take Stiripentol with Thiotepa?
MediHelp rates the interaction as moderate. Stiripentol and Thiotepa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP3A4 and CYP2B6 and may alter the conversion of thiotepa to its active metabolite and its clearance. The clinical effect on toxicity or efficacy is uncertain.
How serious is the interaction between Stiripentol and Thiotepa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used together, monitor for myelosuppression and adjust the thiotepa dose.
What other medicines interact with Stiripentol?
MediHelp also lists interactions of Stiripentol with, for example, Apalutamide, Clomipramine, Ergotamine. The full list is on the Stiripentol page.
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