Drug interactions
Stiripentol + Tofacitinib
Severity: Moderate
Stiripentol and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP2C19 and has mixed effects on CYP3A4, so tofacitinib exposure may rise or fall. Unpredictable levels may cause toxicity or loss of effect.
What this interaction means in plain words
Stiripentol and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Tofacitinib belongs to Musculoskeletal.
Why it happens
Stiripentol inhibits CYP2C19 and both inhibits and induces CYP3A4, altering tofacitinib clearance.
What to do
Monitor efficacy and adverse effects after starting or stopping stiripentol. Adjust the tofacitinib dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Tofacitinib?
MediHelp rates the interaction as moderate. Stiripentol and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP2C19 and has mixed effects on CYP3A4, so tofacitinib exposure may rise or fall. Unpredictable levels may cause toxicity or loss of effect.
How serious is the interaction between Stiripentol and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor efficacy and adverse effects after starting or stopping stiripentol. Adjust the tofacitinib dose as needed.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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