Drug interactions
Stiripentol + Topiramate
Severity: Moderate
Stiripentol and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are antiseizure drugs that cause drowsiness, so combined use increases sedation and somnolence. Stiripentol is also a CYP inhibitor, which may further affect other antiseizure drug levels.
What this interaction means in plain words
Stiripentol and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible pharmacokinetic effects of stiripentol on co-administered agents.
What to do
Monitor for somnolence, ataxia and reduced appetite, especially during titration, and reduce the dose of topiramate or stiripentol if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Stiripentol and Topiramate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Topiramate
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Topiramate?
MediHelp rates the interaction as moderate. Stiripentol and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are antiseizure drugs that cause drowsiness, so combined use increases sedation and somnolence. Stiripentol is also a CYP inhibitor, which may further affect other antiseizure drug levels.
How serious is the interaction between Stiripentol and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for somnolence, ataxia and reduced appetite, especially during titration, and reduce the dose of topiramate or stiripentol if sedation is troublesome.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
