Drug interactions
Stiripentol + Venlafaxine
Severity: Moderate
Stiripentol and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces several CYP enzymes including CYP2D6, CYP3A4 and CYP1A2, so venlafaxine and its active metabolite exposure could change unpredictably. The net clinical effect is not well characterised.
What this interaction means in plain words
Stiripentol and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
Why it happens
Mixed inhibition and induction of CYP enzymes (CYP2D6, CYP3A4) involved in venlafaxine metabolism by stiripentol.
What to do
Monitor clinical response and adverse effects such as blood pressure elevation, nausea and agitation when starting or stopping stiripentol. Adjust the venlafaxine dose according to tolerability and response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Venlafaxine?
MediHelp rates the interaction as moderate. Stiripentol and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces several CYP enzymes including CYP2D6, CYP3A4 and CYP1A2, so venlafaxine and its active metabolite exposure could change unpredictably. The net clinical effect is not well characterised.
How serious is the interaction between Stiripentol and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and adverse effects such as blood pressure elevation, nausea and agitation when starting or stopping stiripentol. Adjust the venlafaxine dose according to tolerability and response.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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