Drug interactions
Stiripentol + Zolpidem
Severity: Moderate
Stiripentol and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol is both an inhibitor and inducer of CYP3A4, so zolpidem exposure may change unpredictably. It also causes somnolence, adding to zolpidem's sedative effect. Excess sedation is the main concern.
What this interaction means in plain words
Stiripentol and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Zolpidem belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction plus additive CNS depression.
What to do
Start with a low zolpidem dose and monitor for both oversedation and loss of effect. Adjust the dose based on clinical response and avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Zolpidem?
MediHelp rates the interaction as moderate. Stiripentol and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol is both an inhibitor and inducer of CYP3A4, so zolpidem exposure may change unpredictably. It also causes somnolence, adding to zolpidem's sedative effect. Excess sedation is the main concern.
How serious is the interaction between Stiripentol and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low zolpidem dose and monitor for both oversedation and loss of effect. Adjust the dose based on clinical response and avoid alcohol.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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