Drug interactions
Streptomycin + Succinylcholine
Severity: Major
Streptomycin and Succinylcholine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides such as streptomycin can impair neuromuscular transmission and may potentiate or prolong the paralysis from succinylcholine. This may lead to prolonged apnea or delayed recovery of respiratory muscle function.
What this interaction means in plain words
Streptomycin and Succinylcholine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Streptomycin belongs to Anti Bacterial; Succinylcholine belongs to Musculoskeletal.
Why it happens
Aminoglycosides reduce presynaptic acetylcholine release and decrease postsynaptic sensitivity, adding to neuromuscular blockade.
What to do
Monitor neuromuscular blockade with nerve stimulation and keep ventilatory support available until full recovery. Avoid giving streptomycin perioperatively when an alternative is possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Succinylcholine
Other interactions of Streptomycin
Frequently asked questions
Can I take Streptomycin with Succinylcholine?
MediHelp rates the interaction as major. Streptomycin and Succinylcholine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aminoglycosides such as streptomycin can impair neuromuscular transmission and may potentiate or prolong the paralysis from succinylcholine. This may lead to prolonged apnea or delayed recovery of respiratory muscle function.
How serious is the interaction between Streptomycin and Succinylcholine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular blockade with nerve stimulation and keep ventilatory support available until full recovery. Avoid giving streptomycin perioperatively when an alternative is possible.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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