Drug interactions
Streptomycin + Tacrolimus
Severity: Major
Streptomycin and Tacrolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus is nephrotoxic and streptomycin is nephrotoxic and ototoxic. Together they raise the risk of acute kidney injury, which in turn reduces aminoglycoside clearance and increases ototoxicity risk.
What this interaction means in plain words
Streptomycin and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Streptomycin belongs to Anti Bacterial; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity, with renal impairment further increasing aminoglycoside accumulation.
What to do
Avoid if alternatives exist; otherwise monitor serum creatinine, streptomycin and tacrolimus levels, and assess hearing and balance. Adjust doses based on renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Streptomycin
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Streptomycin with Tacrolimus?
MediHelp rates the interaction as major. Streptomycin and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tacrolimus is nephrotoxic and streptomycin is nephrotoxic and ototoxic. Together they raise the risk of acute kidney injury, which in turn reduces aminoglycoside clearance and increases ototoxicity risk.
How serious is the interaction between Streptomycin and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if alternatives exist; otherwise monitor serum creatinine, streptomycin and tacrolimus levels, and assess hearing and balance. Adjust doses based on renal function.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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