Drug interactions
Streptomycin + Torsemide
Severity: Major
Streptomycin and Torsemide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics such as torsemide given with aminoglycosides may increase the risk of hearing and vestibular injury, which can be permanent. Volume depletion can also add to aminoglycoside nephrotoxicity.
What this interaction means in plain words
Streptomycin and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Streptomycin belongs to Anti Bacterial; Torsemide belongs to Cardiovascular.
Why it happens
Additive ototoxicity and nephrotoxicity, with diuretic-induced volume depletion raising aminoglycoside exposure.
What to do
Avoid if possible, or use the lowest effective doses with adequate hydration. Monitor renal function, aminoglycoside levels and hearing or balance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Streptomycin
Other interactions of Torsemide
Frequently asked questions
Can I take Streptomycin with Torsemide?
MediHelp rates the interaction as major. Streptomycin and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Loop diuretics such as torsemide given with aminoglycosides may increase the risk of hearing and vestibular injury, which can be permanent. Volume depletion can also add to aminoglycoside nephrotoxicity.
How serious is the interaction between Streptomycin and Torsemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or use the lowest effective doses with adequate hydration. Monitor renal function, aminoglycoside levels and hearing or balance.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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