Drug interactions
Succinylcholine + Tolmetin
Severity: Minor
Succinylcholine and Tolmetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise serum potassium, but the effect of tolmetin is small and mainly relevant in renal impairment. A clinically meaningful additive interaction in typical anesthetic use is unlikely.
What this interaction means in plain words
Succinylcholine and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Succinylcholine belongs to Musculoskeletal; Tolmetin belongs to Musculoskeletal.
Why it happens
Succinylcholine releases potassium from muscle while NSAIDs may reduce renal potassium excretion through suppressed renin and aldosterone; the combined effect is modest.
What to do
No routine change is needed; check potassium preoperatively in patients with renal impairment or other hyperkalemia risks taking an NSAID.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Succinylcholine with Tolmetin?
MediHelp rates the interaction as minor. Succinylcholine and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can raise serum potassium, but the effect of tolmetin is small and mainly relevant in renal impairment. A clinically meaningful additive interaction in typical anesthetic use is unlikely.
How serious is the interaction between Succinylcholine and Tolmetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; check potassium preoperatively in patients with renal impairment or other hyperkalemia risks taking an NSAID.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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