Drug interactions
Succinylcholine + Tolterodine
Severity: Minor
Succinylcholine and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine acts at nicotinic receptors, while tolterodine blocks muscarinic receptors, so there is no clear direct interaction. Any effect is limited to additive heart rate changes such as bradycardia opposed by antimuscarinic action.
What this interaction means in plain words
Succinylcholine and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Succinylcholine belongs to Musculoskeletal; Tolterodine belongs to Genitourinary.
Why it happens
No established mechanism; different receptor targets.
What to do
No specific action is needed beyond standard anesthetic monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Succinylcholine
Frequently asked questions
Can I take Succinylcholine with Tolterodine?
MediHelp rates the interaction as minor. Succinylcholine and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Succinylcholine acts at nicotinic receptors, while tolterodine blocks muscarinic receptors, so there is no clear direct interaction. Any effect is limited to additive heart rate changes such as bradycardia opposed by antimuscarinic action.
How serious is the interaction between Succinylcholine and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond standard anesthetic monitoring.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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