Drug interactions
Sufentanil + Zafirlukast
Severity: Minor
Sufentanil and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast may weakly inhibit CYP3A4, a main pathway for sufentanil clearance. Increased sufentanil exposure could prolong opioid effects including respiratory depression, though a significant effect is unlikely.
What this interaction means in plain words
Sufentanil and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sufentanil belongs to Musculoskeletal; Zafirlukast belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by zafirlukast reduces sufentanil metabolism.
What to do
Monitor sedation and respiratory rate and titrate sufentanil to effect in patients taking zafirlukast.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Sufentanil with Zafirlukast?
MediHelp rates the interaction as minor. Sufentanil and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast may weakly inhibit CYP3A4, a main pathway for sufentanil clearance. Increased sufentanil exposure could prolong opioid effects including respiratory depression, though a significant effect is unlikely.
How serious is the interaction between Sufentanil and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate and titrate sufentanil to effect in patients taking zafirlukast.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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