Drug interactions
Sufentanil sl + Trimipramine
Severity: Major
Sufentanil sl and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sublingual sufentanil with trimipramine increases the risk of CNS and respiratory depression. Serotonin syndrome is also possible, though uncommon.
What this interaction means in plain words
Sufentanil sl and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression, with possible serotonergic effects.
What to do
Monitor respiration and sedation, especially at initiation and dose changes. Watch for agitation, tremor, hyperthermia or clonus suggesting serotonin syndrome.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Sufentanil sl with Trimipramine?
MediHelp rates the interaction as major. Sufentanil sl and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sublingual sufentanil with trimipramine increases the risk of CNS and respiratory depression. Serotonin syndrome is also possible, though uncommon.
How serious is the interaction between Sufentanil sl and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiration and sedation, especially at initiation and dose changes. Watch for agitation, tremor, hyperthermia or clonus suggesting serotonin syndrome.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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