Drug interactions
Sufentanil sl + Vortioxetine
Severity: Moderate
Sufentanil sl and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sublingual sufentanil combined with a serotonergic antidepressant carries a potential risk of serotonin syndrome. Sufentanil also causes respiratory and CNS depression.
What this interaction means in plain words
Sufentanil sl and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from opioid influence on serotonin neurotransmission combined with vortioxetine.
What to do
Monitor for serotonin syndrome features such as agitation, clonus, hyperthermia and diarrhea, especially after dose increases. Use the lowest effective opioid dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Sufentanil sl with Vortioxetine?
MediHelp rates the interaction as moderate. Sufentanil sl and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sublingual sufentanil combined with a serotonergic antidepressant carries a potential risk of serotonin syndrome. Sufentanil also causes respiratory and CNS depression.
How serious is the interaction between Sufentanil sl and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome features such as agitation, clonus, hyperthermia and diarrhea, especially after dose increases. Use the lowest effective opioid dose.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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