Drug interactions
Sulfamethoxazole + Trimipramine
Severity: Moderate
Sulfamethoxazole and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole (usually with trimethoprim) has been linked to QT prolongation and arrhythmia in rare cases, and a tricyclic adds to repolarization risk. Clinical relevance is greatest with other risk factors.
What this interaction means in plain words
Sulfamethoxazole and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive QT prolongation; the sulfonamide contribution is weakly established.
What to do
Check ECG and electrolytes in patients with cardiac disease or additional QT-prolonging drugs. Use an alternative antibiotic if the QTc rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Sulfamethoxazole with Trimipramine?
MediHelp rates the interaction as moderate. Sulfamethoxazole and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfamethoxazole (usually with trimethoprim) has been linked to QT prolongation and arrhythmia in rare cases, and a tricyclic adds to repolarization risk. Clinical relevance is greatest with other risk factors.
How serious is the interaction between Sulfamethoxazole and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with cardiac disease or additional QT-prolonging drugs. Use an alternative antibiotic if the QTc rises.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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