Drug interactions
Sulindac + Tolazamide
Severity: Moderate
Sulindac and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas, occasionally leading to hypoglycemia. Sulindac has been less consistently implicated than some other NSAIDs, but the possibility exists.
What this interaction means in plain words
Sulindac and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sulindac belongs to Musculoskeletal; Tolazamide belongs to Endocrine.
Why it happens
Possible displacement of sulfonylurea from protein binding and prostaglandin-related effects on insulin secretion; the mechanism is not firmly established.
What to do
Monitor blood glucose when sulindac is started or stopped and counsel the patient on hypoglycemia symptoms. Reduce the tolazamide dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Sulindac with Tolazamide?
MediHelp rates the interaction as moderate. Sulindac and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose-lowering effect of sulfonylureas, occasionally leading to hypoglycemia. Sulindac has been less consistently implicated than some other NSAIDs, but the possibility exists.
How serious is the interaction between Sulindac and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when sulindac is started or stopped and counsel the patient on hypoglycemia symptoms. Reduce the tolazamide dose if glucose falls.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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