Drug interactions
Sulindac + Tolbutamide
Severity: Moderate
Sulindac and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulindac may enhance the glucose-lowering effect of tolbutamide, raising the chance of hypoglycemia in some patients. The clinical effect is generally modest and variable between individuals.
What this interaction means in plain words
Sulindac and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sulindac belongs to Musculoskeletal; Tolbutamide belongs to Endocrine.
Why it happens
The mechanism is not firmly established; displacement from protein binding or reduced sulfonylurea clearance has been proposed, and NSAID prostaglandin effects may contribute.
What to do
Monitor blood glucose when sulindac is started or stopped in a patient taking tolbutamide, and reduce the sulfonylurea dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Sulindac with Tolbutamide?
MediHelp rates the interaction as moderate. Sulindac and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulindac may enhance the glucose-lowering effect of tolbutamide, raising the chance of hypoglycemia in some patients. The clinical effect is generally modest and variable between individuals.
How serious is the interaction between Sulindac and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when sulindac is started or stopped in a patient taking tolbutamide, and reduce the sulfonylurea dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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