Drug interactions
Sulindac + Vancomycin
Severity: Minor
Sulindac and Vancomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may lower vancomycin clearance and raise its levels, as reported mainly in neonates treated with indomethacin. Combined nephrotoxic potential adds concern in at-risk patients.
What this interaction means in plain words
Sulindac and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sulindac belongs to Musculoskeletal; Vancomycin belongs to Anti Bacterial.
Why it happens
NSAID inhibition of renal prostaglandins reduces glomerular filtration and vancomycin elimination.
What to do
Monitor renal function and vancomycin trough or AUC levels, particularly in neonates and patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Sulindac with Vancomycin?
MediHelp rates the interaction as minor. Sulindac and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may lower vancomycin clearance and raise its levels, as reported mainly in neonates treated with indomethacin. Combined nephrotoxic potential adds concern in at-risk patients.
How serious is the interaction between Sulindac and Vancomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and vancomycin trough or AUC levels, particularly in neonates and patients with renal impairment.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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